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Exosomes

What are exosomes and why they matter for skin firmness

EXO...WHAT? EXOSOMES, TO THE RESCUE

Smart messengers supporting the skin at every stage

Ever feel like your skin doesn’t quite understand the skincare you apply? Good news: it does. In fact, it’s incredibly receptive, thanks in large part to exosomes. Tiny but powerful players in the most advanced skincare science. Keep reading. You’ll want to know this.


So, what exactly are exosomes?

Imagine ultra-light microbubbles moving through your skin, carrying valuable information. Exosomes are microscopic vesicles released by cells to enhance communication. Inside, they deliver proteins, lipids, and genetic material offering precise instructions that tell other cells what to do, and when to do it.

Exosomes are your skin’s
internal messaging system.  

How do exosomes work in skincare?

Exosomes help cells coordinate essential processes like regeneration and repair. But here’s the key distinction: not all exosome-based cosmetics work the same way.

Some formulas rely on external exosomes, often biomimetic or plant derived. Essential Shock (R)Evolution features an active ingredient working intelligently in sync with the skin’s own mechanisms, respecting its biology and supporting its natural capacity to respond.

Exosomes, menopause, and skin

During menopause, hormonal changes slow many key skin processes: reducing the efficiency of cell renewal, accelerating collagen loss, and diminishing skin density and elasticity.

This is where exosomes take center stage, helping support functions the skin naturally performed before this stage of life.

Pro-Exo Protein System: a boost for your skin

We don’t add external exosomes to Essential Shock (R)Evolution. Instead, we include Pro-Exo Protein Systemℱ, featuring an active ingredient designed to support your skin’s own exosomes, allowing it to receive clearer signals and respond more effectively.

In vitro efficacy studies in the ingredient show this system interacts with the skin microbiome optimizing cellular communication, helping the skin remember how to regenerate and maintain firmness.

This advanced signaling helps to:

  • ✓ Improve the junction between dermis and epidermis
  • ✓ Support the extracellular matrix
  • ✓ Protect against processes that weaken firmness over time
  • ✓ Boost collagen production (types I, III, and IV)

What do exosomes have to do with collagen and elastin?

A lot. A whole lot.

Exosomes play a role in activating fibroblasts—the cells responsible for producing collagen and elastin. When the “get to work” signal arrives clearly and on time, these cells can produce structural fibers more efficiently.

Translated in the mirror:

  • ★ Boosted firmness
  • ★ Increased elasticity
  • ★ Increased density
  • ★ Skin looking stronger and more resilient

Pro-longevity Skincare

At Natura BissĂ©, we understand skincare as a long-term strategy. That’s why our formulas are designed to support the skin’s biological intelligence—helping it perform better today and stay beautiful over time.

Longevity science points to cellular communication as one of the 12 hallmarks of aging well. With this philosophy in mind, we create products like Essential Shock (R)Evolution serum and cream, featuring the pro-exosome complex Pro-Exo Protein Systemℱ.

Descubre nuestro trĂ­o pro-exosomas

LO QUIERO

Scientific resources

  • ïč’Raposo, G. & Stoorvogel, W. Extracellular vesicles: exosomes, microvesicles, and friends. Journal of Cell Biology, 2013. 
  • ïč’Kalluri, R. & LeBleu, V.S. The biology, function, and biomedical applications of exosomes. Science, 2020. 
  • ïč’Liang, C., Yi, Y., Li, J., Aghayants, S., Chen, X., Cao, W., & Zhang, Q. (2025). Unveiling exosomes in combating skin aging: Insights into resources, mechanisms and challenges. Stem Cell Research & Therapy, 16, 474.
  • ïč’Sreeraj, H., AnuKiruthika, R., Tamilselvi, K. S., & Subha, D. (2024). Exosomes for skin treatment: Therapeutic and cosmetic applications. Nanotechnology for Medicine, 100048.Â